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KMID : 0606920130210020121
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Biomolecules & Therapeutics
2013 Volume.21 No. 2 p.121 ~ p.125
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Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells
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Kim Hye-Young
Park Min
Kim Kyong
Lee Yu-Mi
Rhyu Mee-Ra
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Abstract
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Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on suppressive effects on appetite. This study examined that hesperetin and hesperidin can stimulate the release of cholecystokinin (CCK), one of appetite-regulating hormones, from the enteroendocrine STC-1 cells, and then examined the mechanisms involved in the CCK release. Hesperetin significantly and dose-dependently stimulated CCK secretion with an EC50 of 0.050 mM and increased the intracellular Ca2+ concentrations ([Ca2+]i) compared to the untreated control. The stimulatory effect by hesperetin was mediated via the entry of extracellular Ca2+ and the activation of TRP channels including TRPA1. These results suggest that hesperetin can be a candidate biomolecule for the suppression of appetite and eventually for the therapeutics of obesity.
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KEYWORD
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Hesperetin, Cholecystokinin, Intracellular Ca2+, TRP ankyrin 1, Enteroendocrine cells
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